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It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
A comparison of a mouse unable to produce leptin thus resulting in obesity (left) and a normal mouse (right). The ob/ob or obese mouse is a mutant mouse that eats excessively due to mutations in the gene responsible for the production of leptin and becomes profoundly obese.
Unlike most laboratory mouse strains, the C57BL/6 drinks alcoholic beverages voluntarily. It is more susceptible than average to morphine addiction, atherosclerosis, and age-related hearing loss. [11] When compared directly to BALB/c mice, C57BL/6 mice also express both a robust response to social rewards [43] [44] and empathy. [45]
Approximately 60% of FVB Mice regardless of sex survive to two years of age. [6] By this point, approximately 60% of surviving mice show tumors/lesions. Some sudden deaths are observed in younger animals, but most die at 15 months or older. Two years is a common life expectancy in wild-type house mice.
C57BL/6 was created by Clarence Little, the first director and founder of JAX. However, he created the strain in 1921 (see here on the JAX site), whereas the Jackson Labs didn't come into being until 1929. In addition, JAX may be the largest supplier of C57BL/6J, but it probably is not the largest supplier of some other substrains, such as ...
Charles River was founded in 1947 by Henry Foster, a young veterinarian who purchased one thousand rat cages from a Virginia farm and set up a one-person laboratory in Boston overlooking the Charles River. To fulfill the regional need for laboratory animal models, he bred, fed, and cared for the animals and personally delivered them to local ...
The incidence of spontaneous diabetes in the NOD mouse is 60–80% in females and 20–30% in males. Onset of diabetes also varies between males and females: commonly, onset is delayed in males by several weeks. The mice (as well as C57BL/6 and SJL) are known to carry IgG2c allele. [4] [5]
The Charles River (Massachusett: Quinobequin), sometimes called the River Charles or simply the Charles, is an 80-mile-long (129 km) river in eastern Massachusetts.It flows northeast from Hopkinton to Boston along a highly meandering route, that doubles back on itself several times and travels through 23 cities and towns before reaching the Atlantic Ocean. [1]