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It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
[6] [2] [4] Existing resistant strains of mice, such as C57BL/6, C57BL/10 and AKR, may not have clinical signs that viruses can cause for other animals. [7] It is important to note that the genetic background of the mouse can affect the infection, which means that host factors are involved in the regulation of susceptibility and resistance to ...
Unlike most laboratory mouse strains, the C57BL/6 drinks alcoholic beverages voluntarily. It is more susceptible than average to morphine addiction, atherosclerosis, and age-related hearing loss. [11] When compared directly to BALB/c mice, C57BL/6 mice also express both a robust response to social rewards [43] [44] and empathy. [45]
C57BL/6 was created by Clarence Little, the first director and founder of JAX. However, he created the strain in 1921 (see here on the JAX site), whereas the Jackson Labs didn't come into being until 1929. In addition, JAX may be the largest supplier of C57BL/6J, but it probably is not the largest supplier of some other substrains, such as ...
Non-native house mice are eating seabirds alive on South Africa’s remote Marion Island. Call to support island mice eradication bid after latest attack on albatross Skip to main content
Charles River was founded in 1947 by Henry Foster, a young veterinarian who purchased one thousand rat cages from a Virginia farm and set up a one-person laboratory in Boston overlooking the Charles River. To fulfill the regional need for laboratory animal models, he bred, fed, and cared for the animals and personally delivered them to local ...
In the UK in 2015, there were 3.33 million procedures on rodents (80% of total procedures that year). The most common species used were mice (3.03 million procedures, or 73% of the total) and rats (268,522, or 6.5%).
Female mice in the dangerous living environment group, showed higher levels of fecal corticosterone, and minimal maternal care compared to the females in the safe environment group. Furthermore, a dangerous environment inherently provides infanticide threats to female mice, increasing the likelihood that corticosterone concentrations will ...