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The drug possess a biological half-life of 14 days when administered by intramuscular injection. [1] Boldenone is a substrate for 5α-reductase and may be converted by this enzyme into 1-testosterone (δ 1 -dihydrotestosterone, δ 1 -DHT, dihydroboldenone) in tissues that express it such as the skin , hair follicles , and prostate gland . [ 6 ]
Anti-thymocyte globulin (ATG) is an infusion of horse or rabbit-derived antibodies against human T cells and their precursors , which is used in the prevention and treatment of acute rejection in organ transplantation and therapy of aplastic anemia due to bone marrow insufficiency.
Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), analgesic, and antipyretic used in horses, cattle and pigs. It is often formulated as the meglumine salt.In the United States, it is regulated by the U.S. Food and Drug Administration (FDA), and may only be lawfully distributed by order of a licensed veterinarian.
The 1901 diphtheria antitoxin contamination incident, in which the milk wagon horse used to culture the antitoxin became infected with tetanus, which contaminated vials of the antitoxin leading to the deaths of several children in the midwest United States, [5] led to the passage of the Biologics Control Act of 1902 and the 1906 formation of ...
Side effects from intra-articular administration can include joint pain, swelling, lameness, and, rarely, infection of the joint. Intramuscular injection can cause dose-dependent inflammation and bleeding, since PSGAG is an analogue of the anticoagulant heparin. [4] In dogs, this may manifest as bleeding from the nose or as bloody stools. [7]
Butorphanol is a narcotic used for pain relief in horses. [15] It is administered either IM or IV, with its analgesic properties beginning to take effect about 15 minutes after injection and lasting 4 hours. [16] It is also commonly paired with sedatives, such as xylazine and detomidine, to make the horse easier to handle during veterinary ...
The treatment of equine lameness is a complex subject. Lameness in horses has a variety of causes, and treatment must be tailored to the type and degree of injury, as well as the financial capabilities of the owner. Treatment may be applied locally, systemically, or intralesionally, and the strategy for treatment may change as healing progresses.
Promazine, given as promazine hydrochloride, is one of the primary tranquilizers used by veterinarians as a pre-anaesthesia injection in horses. [ 7 ] [ 8 ] It does not provide analgesia and is not a very strong sedative, hence it is used combined with opioids or α 2 adrenoreceptor agonists , such as clonidine , or both.