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AP-1 was first discovered as a TPA-activated transcription factor that bound to a cis-regulatory element of the human metallothionein IIa promoter and SV40. [3] The AP-1 binding site was identified as the 12-O-Tetradecanoylphorbol-13-acetate response element (TRE) with the consensus sequence 5’-TGA G/C TCA-3’. [4]
The AP-1 binding site, also known as the AP-1 promoter site, is a DNA sequence to which AP-1 transcription factors are able to bind. [1] The AP-1 binding site, in humans, has a nucleotide sequence of ATGAGTCAT, where A corresponds to adenine, T corresponds to thymine, G corresponds to guanine, and C corresponds to cytosine.
Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor ...
The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2.These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1.
16477 Ensembl ENSG00000171223 ENSMUSG00000052837 UniProt P17275 P09450 RefSeq (mRNA) NM_002229 NM_008416 RefSeq (protein) NP_002220 NP_032442 Location (UCSC) Chr 19: 12.79 – 12.79 Mb Chr 8: 85.7 – 85.71 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor jun-B is a protein that, in humans, is encoded by the JUNB gene. Transcription factor jun-B is a transcription ...
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