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Potassium channel blockers exhibit reverse use-dependent prolongation of the action potential duration. Reverse use dependence is the effect where the efficacy of the drug is reduced after repeated use of the tissue. [11] This contrasts with (ordinary) use dependence, where the efficacy of the drug is increased after repeated use of the tissue.
According to the FDA, sotalol should not be used in people with a waking heart rate lower than 50 beats per minute. [8] It should not be used in people with sick sinus syndrome, long QT syndrome, cardiogenic shock, uncontrolled heart failure, asthma or a related bronchospastic condition, or people with serum potassium below 4 meq/L. [8] It should only be used in people with a second and third ...
DPH-362 is a simplified amitriptyline analog created by omission of the two-carbon dibenzosuberane bridge (the seven membered ring). The resulting compound still had activity in a test to explore TCA sodium channel blockers with analgesic properties.
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A potassium channel opener is a type of drug which facilitates ion transmission through potassium ... Potassium channel blocker; References This page was last ...
Researchers have tested a nasal spray aiming to fight toxic protein accumulations in the brains of mouse models of Alzheimer's disease. Their findings so far show promise.