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Sotalol, sold under the brand name Betapace among others, is a medication used to treat and prevent abnormal heart rhythms. [1] Evidence does not support a decreased risk of death with long term use. [1] It is taken by mouth or given by injection into a vein. [1]
Sotalol is also a beta blocker [5] Amiodarone has mostly Class III activity, but also I, II, & IV activity [6] Prevent paroxysmal atrial fibrillation [7] and haemodynamically stable ventricular tachycardia [8] (amiodarone) Treat atrial flutter and atrial fibrillation (ibutilide) Treat ventricular tachycardia and atrial fibrillation (sotalol)
Sotalol, in particular, has additional antiarrhythmic properties and prolongs action potential duration through potassium channel blockade. Blockade of the sympathetic nervous system on renin release leads to reduced aldosterone via the renin–angiotensin–aldosterone system , with a resultant decrease in blood pressure due to decreased ...
It can be taken orally or by intravenous injection. [2] The formulation that is taken orally comes in short-acting and long-acting versions. [2] Propranolol appears in the blood after 30 minutes and has a maximum effect between 60 and 90 minutes when taken orally. [2] [6] Common side effects include nausea, abdominal pain, and constipation. [2]
Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias. [4] This includes ventricular tachycardia, ventricular fibrillation, and wide complex tachycardia, atrial fibrillation, and paroxysmal supraventricular tachycardia. [4]
Mexiletine (sold under the brand names Mexitil and Namuscla) is a medication used to treat abnormal heart rhythms, chronic pain, and some causes of muscle stiffness.. Common side effects include abdominal pain, chest discomfort, drowsiness, headache, and n