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Roblox is an online game platform and game creation system built around user-generated content and games, [1] [2] officially referred to as "experiences". [3] Games can be created by any user through the platforms game engine, Roblox Studio, [4] and then shared to and played by other players. [1]
BK channels (big potassium), are large conductance calcium-activated potassium channels, [1] also known as Maxi-K, slo1, or Kca1.1. BK channels are voltage-gated potassium channels that conduct large amounts of potassium ions (K + ) across the cell membrane , hence their name, big potassium .
Potassium is a chemical element; it has symbol K (from Neo-Latin kalium) and atomic number 19. It is a silvery white metal that is soft enough to easily cut with a knife. [9] Potassium metal reacts rapidly with atmospheric oxygen to form flaky white potassium peroxide in only seconds of exposure.
Potassium channels are the most widely distributed type of ion channel found in virtually all organisms. [1] They form potassium-selective pores that span cell membranes.
Hypokalemia is a low level of potassium (K +) in the blood serum. [1] Mild low potassium does not typically cause symptoms. [3] Symptoms may include feeling tired, leg cramps, weakness, and constipation. [1]
Four genes have been identified as members of the K ATP gene family. The sur1 and kir6.2 genes are located in chr11p15.1 while kir6.1 and sur2 genes reside in chr12p12.1. The kir6.1 and kir6.2 genes encode the pore-forming subunits of the K ATP channel, with the SUR subunits being encoded by the sur1 (SUR1) gene or selective splicing of the sur2 gene (SUR2A and SUR2B).
K ir export surplus potassium into collecting tubules for removal in the urine, or alternatively may be involved in the reuptake of potassium back into the body. neurons and in heart cells: G-protein activated IRKs (K ir 3) are important regulators, modulated by neurotransmitters. A mutation in the GIRK2 channel leads to the weaver mouse mutation.
Potassium resides mainly inside the cells of the body, so its concentration in the blood can range anywhere from 3.5 mEq/L to 5 mEq/L. [14] The kidneys are responsible for excreting the majority of potassium from the body. [14] This means their function is crucial for maintaining a proper balance of potassium in the blood stream.