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Pedicels interdigitate, thereby giving rise to thin gaps called filtration slits. [3] The slits are covered by slit diaphragms which are composed of a number of cell-surface proteins including nephrin , podocalyxin , and P-cadherin , which restrict the passage of large macromolecules such as serum albumin and gamma globulin and ensure that they ...
The renal hilum or renal pedicle is the recessed central fissure of the kidney where its vessels, nerves and ureter pass. The medial border of the kidney is concave in the center and convex toward either extremity; it is directed forward and a little downward.
These pedicels interdigitate with pedicels of adjacent podocytes forming filtration slits. There are two poles in the renal corpuscle, a vascular pole and a tubular pole . [ 4 ] The vascular pole is a location of the glomerulus.
The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus.The glomerular endothelial cells, the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule. [1]
Pedicle of vertebral arch, the segment between the transverse process and the vertebral body, and is often used as a radiographic marker and entry point in vertebroplasty and kyphoplasty procedures; Pedicle of a skin flap (medicine) Hilum of kidney, also called the renal pedicle; Pedicel, a foot process of a some cells
The podocyte is a highly specialised epithelial cell in Bowman's capsule in the kidney. Primary processes of the podocytes form terminal foot processes. The podocyte foot processes wrap around the glomerular capillaries in the kidney to function in the filtration barrier.
The surgery is performed with the patient under general anesthesia. A kidney can be removed through an open incision or by laparoscopic surgery. For the open procedure, the surgeon makes an incision in the side of the abdomen to reach the kidney. Depending on circumstances, the incision can also be made midline.
It is used when the kidneys are not working well, which is called kidney failure and includes acute kidney injury and chronic kidney disease. Renal replacement therapy includes dialysis (hemodialysis or peritoneal dialysis), hemofiltration, and hemodiafiltration, which are various ways of filtration of blood with or without machines.