Search results
Results From The WOW.Com Content Network
Autoimmune GFAP Astrocytopathy is an autoimmune disease in which the immune system of the patient attacks a protein of the nervous system called glial fibrillary acidic protein (GFAP). It was described in 2016 by researchers of the Mayo Clinic in the United States.
Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans. [5] It is a type III intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS), including astrocytes [ 6 ] and ependymal cells during development. [ 7 ]
Autoimmune GFAP astrocytopathy; Autoimmune hemolytic anemia; Autoimmune hypophysitis; Autoimmune inner ear disease; Autoimmune oophoritis; Autoimmune pancreatitis; Autoimmune polyendocrine syndrome; Autoimmune polyendocrine syndrome type 1; Autoimmune polyendocrine syndrome type 2; Autoimmune polyendocrine syndrome type 3; Autoimmune retinopathy
Type 1: Antigenically Ran2 +, GFAP +, FGFR3 +, A2B5 −, thus resembling the "type 1 astrocyte" of the postnatal day 7 rat optic nerve. These can arise from the tripotential glial restricted precursor cells (GRP), but not from the bipotential O2A/OPC (oligodendrocyte, type 2 astrocyte precursor, also called Oligodendrocyte progenitor cell ) cells.
In 2016, it was identified in Mayo clinic an autoimmune form of myelitis due to the presence of anti-GFAP autoantibodies. Immunoglobulins directed against the α-isoform of glial fibrillary acidic protein (GFAP-IgG) predicted a special meningoencephalomyelitis termed autoimmune GFAP Astrocytopathy [ 10 ] that later was found also to be able to ...
Reactive astrogliosis is a spectrum of changes in astrocytes that occur in response to all forms of CNS injury and disease. Changes due to reactive astrogliosis vary with the severity of the CNS insult along a graduated continuum of progressive alterations in molecular expression, progressive cellular hypertrophy, proliferation and scar formation.
GFAP may refer to: Glial fibrillary acidic protein; General Framework Agreement for Peace in Bosnia and Herzegovina, also known as the Dayton Agreement
This page was last edited on 7 May 2015, at 17:34 (UTC).; Text is available under the