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In cell biology, a phagosome is a vesicle formed around a particle engulfed by a phagocyte via phagocytosis. Professional phagocytes include macrophages, neutrophils, and dendritic cells (DCs). [1] A phagosome is formed by the fusion of the cell membrane around a microorganism, a senescent cell or an apoptotic cell.
Advanced Placement (AP) Human Geography (also known as AP Human Geo, AP Geography, APHG, AP HuGe, APHug, AP Human, HuGS, AP HuGo, or HGAP) is an Advanced Placement social studies course in human geography for high school, usually freshmen students in the US, culminating in an exam administered by the College Board. [1]
The phagocyte then stretches itself around the bacterium and engulfs it. Phagocytosis of bacteria by human neutrophils takes on average nine minutes. [25] Once inside this phagocyte, the bacterium is trapped in a compartment called a phagosome. Within one minute the phagosome merges with either a lysosome or a granule to form a phagolysosome.
Phagosome Formation: Once the phagocytic cup has almost completely surrounded the target, the membrane extensions seal together, forming an intact phagosome containing the engulfed material. [9] Phagosome Maturation: The newly formed phagosome undergoes a series of transitions similar to endosome maturation. This process involves the recycling ...
Phagocytosis (from Ancient Greek φαγεῖν (phagein) ' to eat ' and κύτος (kytos) ' cell ') is the process by which a cell uses its plasma membrane to engulf a large particle (≥ 0.5 μm), giving rise to an internal compartment called the phagosome. It is one type of endocytosis. A cell that performs phagocytosis is called a phagocyte.
When a phagocytic cell engulfs bacteria, a phagosome is formed around it and the entire complex is ultimately trafficked to the lysosome for degradation. These cells that participate in the non-specific immune system response do not differentiate between types of microorganisms but do have the ability to discern between what is self and what is ...
NADPH oxidase (nicotinamide adenine dinucleotide phosphate oxidase) is a membrane-bound enzyme complex that faces the extracellular space. It can be found in the plasma membrane as well as in the membranes of phagosomes used by neutrophil white blood cells to engulf microorganisms.
In immunology, the mononuclear phagocyte system or mononuclear phagocytic system (MPS) also known as the macrophage system is a part of the immune system that consists of the phagocytic cells [1] located in reticular connective tissue. The cells are primarily monocytes and macrophages, and they accumulate in lymph nodes and the spleen.