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Serum creatinine (a blood measurement) is an important indicator of kidney function, because it is an easily measured byproduct of muscle metabolism that is excreted unchanged by the kidneys. Creatinine itself is produced [5] via a biological system involving creatine, phosphocreatine (also known as creatine phosphate), and adenosine ...
Creatinine clearance (C Cr) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR. Creatinine clearance exceeds GFR due to creatinine secretion, [ 4 ] which can be blocked by cimetidine .
The glomerular filtration rate is the flow rate of filtered fluid through the kidney. The creatinine clearance rate (C Cr or CrCl) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR. Creatinine clearance exceeds GFR due to creatinine secretion, [1] which can be blocked by ...
In medicine, the urea-to-creatinine ratio (UCR[1]), known in the United States as BUN-to-creatinine ratio, is the ratio of the blood levels of urea (BUN) (mmol/L) and creatinine (Cr) (μmol/L). BUN only reflects the nitrogen content of urea (MW 28) and urea measurement reflects the whole of the molecule (MW 60), urea is just over twice BUN (60/ ...
Clearance (pharmacology) In pharmacology, clearance ( ) is a pharmacokinetic parameter representing the efficiency of drug elimination. This is the rate of elimination of a substance divided by its concentration. [1] The parameter also indicates the theoretical volume of plasma from which a substance would be completely removed per unit time.
Renal physiology (Latin rēnēs, "kidneys") is the study of the physiology of the kidney. This encompasses all functions of the kidney, including maintenance of acid-base balance; regulation of fluid balance; regulation of sodium, potassium, and other electrolytes; clearance of toxins; absorption of glucose, amino acids, and other small ...
Augmented renal clearance. In pharmacology, augmented renal clearance (ARC) is a phenomenon where certain critically ill patients may display increased clearance of a medication through the kidneys. In many cases, it is observed as a measured creatinine clearance above that which is expected given the patient's age, gender, and other factors.
The renal clearance ratio or fractional excretion is a relative measure of the speed at which a constituent of urine passes through the kidneys. [1][2] It is defined by following equation: C in is the renal plasma clearance of inulin. Creatinine is sometimes used instead of inulin as the reference substance; for example, the calcium-creatinine ...