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2. IGFBP3 - Wikipedia

   en.wikipedia.org/wiki/IGFBP3

   IGFBP3. Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene. IGFBP-3 is one of six IGF binding proteins (IGFBP-1 to IGFBP-6) that have highly conserved structures and bind the insulin-like growth factors IGF-1 and IGF-2 with high affinity.

3. Insulin-like growth factor - Wikipedia

   en.wikipedia.org/wiki/Insulin-like_growth_factor

   Insulin-like growth factor 1 (commonly referred to as IGF-1 or at times using Roman numerals as IGF-I) is mainly secreted by the liver as a result of stimulation by growth hormone (GH). IGF-1 is important for both the regulation of normal physiology, as well as a number of pathological states, including cancer.

4. Insulin-like growth factor-binding protein - Wikipedia

   en.wikipedia.org/wiki/Insulin-like_growth_factor...

   IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. IGF-BP also binds to IGF-1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF-1. IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology with ...

5. Insulin-like growth factor 1 - Wikipedia

   en.wikipedia.org/wiki/Insulin-like_growth_factor_1

   Insulin-like growth factor 1. Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults. [5] In the 1950s IGF-1 was called " sulfation factor" because it stimulated sulfation of cartilage in vitro ...

6. Laron syndrome - Wikipedia

   en.wikipedia.org/wiki/Laron_syndrome

   Laron syndrome (LS), also known as growth hormone insensitivity or growth hormone receptor deficiency (GHRD), is an autosomal recessive disorder characterized by a lack of insulin-like growth factor 1 (IGF-1; somatomedin-C) production in response to growth hormone (GH; hGH; somatotropin). [6] It is usually caused by inherited growth hormone ...

7. Growth hormone-binding protein - Wikipedia

   en.wikipedia.org/wiki/Growth_hormone-binding_protein

   Growth hormone-binding protein (GHBP) is a soluble carrier protein for growth hormone (GH). [1] The full range of functions of GHBP remains to be determined [2] [3] however, current research suggests that the protein is associated with regulation of the GH availability and half-life in the circulatory system, as well as modulating GH receptor function.