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  2. Reye syndrome - Wikipedia

    en.wikipedia.org/wiki/Reye_syndrome

    The syndrome is associated with changes on blood tests such as a high blood ammonia level, low blood sugar level, and prolonged prothrombin time. [2] Often, the liver is enlarged in those who have the syndrome. [2] Prevention is typically by avoiding the use of aspirin in children. [1]

  3. Prothrombin time - Wikipedia

    en.wikipedia.org/wiki/Prothrombin_time

    The prothrombin time ratio is the ratio of a subject's measured prothrombin time (in seconds) to the normal laboratory reference PT. The PT ratio varies depending on the specific reagents used, and has been replaced by the INR. [3] Elevated INR may be useful as a rapid and inexpensive diagnostic of infection in people with COVID-19. [4]

  4. Disseminated intravascular coagulation - Wikipedia

    en.wikipedia.org/wiki/Disseminated_intravascular...

    Prolongation of the prothrombin time (PT) and the activated partial thromboplastin time (aPTT) reflect the underlying consumption and impaired synthesis of the coagulation cascade. Fibrinogen level was initially thought to be useful in the diagnosis of DIC but because it is an acute phase reactant, it will be elevated due to the underlying ...

  5. Clotting time - Wikipedia

    en.wikipedia.org/wiki/Clotting_time

    Clotting time is a general term for the time required for a sample of blood to form a clot, or, in medical terms, coagulate.The term "clotting time" is often used when referring to tests such as the prothrombin time (PT), activated partial thromboplastin time (aPTT or PTT), activated clotting time (ACT), thrombin time (TT), or Reptilase time.

  6. Acute liver failure - Wikipedia

    en.wikipedia.org/wiki/Acute_liver_failure

    If the prothrombin time is prolonged by ≈ 4–6 seconds or more (INR ≥ 1.5), and there is any evidence of altered sensorium, the diagnosis of ALF should be strongly suspected, and hospital admission is mandatory. [22] Initial laboratory examination must be extensive in order to evaluate both the etiology and severity.

  7. Coagulopathy - Wikipedia

    en.wikipedia.org/wiki/Coagulopathy

    Coagulopathy (also called a bleeding disorder) is a condition in which the blood's ability to coagulate (form clots) is impaired. [1] This condition can cause a tendency toward prolonged or excessive bleeding (bleeding diathesis), which may occur spontaneously or following an injury or medical and dental procedures.

  8. Thrombophilia - Wikipedia

    en.wikipedia.org/wiki/Thrombophilia

    Two years later, the same group described a common mutation in the prothrombin gene that caused elevation of prothrombin levels and a mild increase in thrombosis risk. [ 4 ] [ 5 ] [ 52 ] It is suspected that other genetic abnormalities underlying familial thrombosis will in future be discovered through studies of the entire genetic code ...

  9. Purpura fulminans - Wikipedia

    en.wikipedia.org/wiki/Purpura_fulminans

    The amount of fresh frozen plasma required to reverse disseminated intravascular coagulation associated with purpura fulminans may lead to complications of fluid overload and death, especially in neonates, [7] such as transfusion-related acute lung injury. Exposure to multiple plasma donors over time increases the cumulative risk for ...