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The respiratory exchange ratio (RER) is the ratio between the metabolic production of carbon dioxide (CO 2) and the uptake of oxygen (O 2). [3] [4] The ratio is determined by comparing exhaled gases to room air. Measuring this ratio is equal to RQ only at rest or during mild to moderate aerobic exercise without the accumulation of lactate.
The alveolar oxygen partial pressure is lower than the atmospheric O 2 partial pressure for two reasons.. Firstly, as the air enters the lungs, it is humidified by the upper airway and thus the partial pressure of water vapour (47 mmHg) reduces the oxygen partial pressure to about 150 mmHg.
A lower V/Q ratio (with respect to the expected value for a particular lung area in a defined position) impairs pulmonary gas exchange and is a cause of low arterial partial pressure of oxygen (pO 2). Excretion of carbon dioxide is also impaired, but a rise in the arterial partial pressure of carbon dioxide (pCO 2) is very uncommon because this ...
The total concentration of carbon dioxide (in the form of bicarbonate ions, dissolved CO 2, and carbamino groups) in arterial blood (i.e. after it has equilibrated with the alveolar air) is about 26 mM (or 58 ml/100 ml), [27] compared to the concentration of oxygen in saturated arterial blood of about 9 mM (or 20 ml/100 ml blood).
Dead space reduces the amount of fresh breathing gas which reaches the alveoli during each breath. This reduces the oxygen available for gas exchange, and the amount of carbon dioxide that can be removed. The buildup of carbon dioxide is usually the more noticeable effect unless the breathing gas is hypoxic as occurs at high altitude.
The concentration of carbon dioxide (CO 2) rises in the blood when the metabolic use of oxygen (O 2), and the production of CO 2 is increased during, for example, exercise. The CO 2 in the blood is transported largely as bicarbonate (HCO 3 − ) ions, by conversion first to carbonic acid (H 2 CO 3 ), by the enzyme carbonic anhydrase , and then ...
The ideal V/Q ratio is 1, the most efficient state of pulmonary function when the amount of oxygen entering the lungs equals the amount of oxygen delivered to the body. Furthermore, adequate achievement of ventilation and perfusion matching is essential as it ensures the continuous supply of oxygen and withdrawal of waste products from the body.
In normal physiology, gas exchange of oxygen and carbon dioxide occurs at the level of the alveoli in the lungs. The existence of a shunt refers to any process that hinders this gas exchange, leading to wasted oxygen inspired and the flow of un-oxygenated blood back to the left heart, which ultimately supplies the rest of the body with de ...