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Chromosome 3 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. People normally have two copies of this chromosome. Chromosome 3 spans more than 198 million base pairs (the building material of DNA ) and represents about 6.5 percent of the total DNA in cells .
The human c-Raf gene is located on chromosome 3. At least two isoforms of mRNA have been described (arising from inclusion or removal of an alternative exon) that display only minute differences. The shorter, major isoform - consisting of 17 exons - encodes a protein kinase of 648 amino acids. [16] A schematic architecture of human c-Raf protein
The TP53 gene is the most frequently mutated gene (>50%) in human cancer, indicating that the TP53 gene plays a crucial role in preventing cancer formation. [5] TP53 gene encodes proteins that bind to DNA and regulate gene expression to prevent mutations of the genome. [ 12 ]
B- and T-lymphocyte attenuator or BTLA (also known as cluster of differentiation 272 or CD272) is a protein that belongs to the CD28 immunoglobulin superfamily (IgSF) which is encoded by the BTLA gene located on the 3rd human chromosome. [5] [6] BTLA was first discovered in 2003 as an inhibitor of Th1 expansion and it became the 3rd member of ...
3) HIV enters the cell. C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines. [5] In humans, the CCR5 gene that encodes the CCR5 protein is located on the short (p) arm at position 21 on chromosome 3.
•List of human protein-coding genes page 2 covers genes EPHA1–MTMR3 •List of human protein-coding genes page 3 covers genes MTMR4–SLC17A7 •List of human protein-coding genes page 4 covers genes SLC17A8–ZZZ3 NB: Each list page contains 5000 human protein-coding genes, sorted alphanumerically by the HGNC-approved gene symbol.
The lambda repressor gene system consists of (from left to right on the chromosome): cI gene; O R 3; O R 2; O R 1; cro gene; The lambda repressor is a self assembling dimer also known as the cI protein. [24] It binds DNA in the helix-turn-helix binding motif. It regulates the transcription of the cI protein and the Cro protein.
Viral genomes can be made up of single stranded DNA , double stranded DNA and can be found in both linear and circular form. [41] One example of infection of a virus constituting as extrachromosomal DNA is the human papillomavirus . The HPV DNA genome undergoes three distinct stages of replication: establishment, maintenance and amplification.