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Odiele was born on 8 October 1988 in Kortrijk, Belgium. [1] They were born with unspecified variant of androgen insensitivity syndrome. [3] [4]As a child, Odiele underwent medical procedures relating to their condition, [5] which they said took place without their or their parents' informed consent. [6]
Androgen insensitivity syndrome (AIS) is a condition involving the inability to respond to androgens, ... Hanne Gaby Odiele [167] [168] Santhi Soundarajan [169] [170]
Complete androgen insensitivity syndrome (CAIS) is an AIS condition that results in the complete inability of the cell to respond to androgens. [1] [2] [3] As such, the insensitivity to androgens is only clinically significant when it occurs in individuals who are exposed to significant amounts of testosterone at some point in their lives. [1]
Bobby Joe Long, a U.S. serial killer with Klinefelter syndrome. Ricardo López, a Uruguayan-American with Klinefelter syndrome who stalked and attempted to murder Icelandic singer Björk in 1996. Small Luk, intersex activist living in Hong Kong, founder of Beyond the Boundary – Knowing and Concerns Intersex [25]
Mild androgen insensitivity syndrome (MAIS) is a condition that results in a mild impairment of the cell's ability to respond to androgens. [1] [2] [3] The degree of impairment is sufficient to impair spermatogenesis and / or the development of secondary sexual characteristics at puberty in males, but does not affect genital differentiation or development.
Those with complete androgen insensitivity syndrome have a 3.6 percent chance of developing a malignant tumor by age 25 and a 33 percent chance by age 50, though malignancy before adulthood is rare. [47] [49] In contrast, partial androgen insensitivity syndrome poses a higher cancer risks if undescended testes are present. [49]
It can be caused by medications such as gonadotropins, [2] gonadotropin-releasing hormone agonists, nonsteroidal antiandrogens, [3] [4] and selective estrogen receptor modulators, as well as conditions like human chorionic gonadotropin-secreting tumors, complete androgen insensitivity syndrome, and estrogen insensitivity syndrome. [5]
Individuals with complete androgen insensitivity syndrome are almost always brought up as females, and the differentiation of gender identity/role is feminine. [8] This example is important in demonstrating that chromosomes and gonads alone do not dictate gender identity and role. [8]