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Famotidine, sold under the brand name Pepcid among others, is a histamine H 2 receptor antagonist medication that decreases stomach acid production. [4] It is used to treat peptic ulcer disease , gastroesophageal reflux disease , and Zollinger-Ellison syndrome . [ 4 ]
Addiction to taking it ("a habit") was how some of its users described Zantac. [10] The focus of Glaxo , its manufacturer, was to gain market share "from Zantac competitors like Tagamet." [ 9 ] Cimetidine , sold under the brand name Tagamet among others, was listed in 2020 as an alternative to Zantac.
Ibuprofen/famotidine, sold under the brand name Duexis, is a fixed-dose combination medication used for the treatment of rheumatoid arthritis and osteoarthritis. [1] It contains ibuprofen , a nonsteroidal anti-inflammatory drug (NSAID) and famotidine, a histamine H2-receptor antagonist .
The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.
Ranitidine has 10% of the affinity that cimetidine has to CYP450, so it causes fewer side effects, but other H 2 blockers famotidine and nizatidine have no CYP450 significant interactions. [ 131 ] Ranitidine was introduced in 1981, and was the world's biggest-selling prescription drug by 1987. [ 132 ]
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