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The term MGRS was introduced in 2012 by the International Kidney and Monoclonal Gammopathy Research Group (IKMG). MGRS is associated with monoclonal gammopathy of undetermined significance (MGUS). People with MGUS have a monoclonal gammopathy (presence of monoclonal immunoglobulins) but does not meet the criteria for the clonal burden nor the ...
MGUS resembles multiple myeloma and similar diseases, but the levels of antibodies are lower, [2] the number of plasma cells (white blood cells that secrete antibodies) in the bone marrow is lower, and it rarely has symptoms or major problems. However, since MGUS can lead to multiple myeloma, which develops at the rate of about 1.5% a year, or ...
As MGUS evolves into MM, another pre-stage of the disease is reached, known as smoldering myeloma (SMM). [15] In MM, the abnormal plasma cells produce abnormal antibodies, which can cause kidney problems and overly thick blood. [10] The plasma cells can also form a mass in the bone marrow or soft tissue. [10]
AKI - the other main type of kidney disease - can be caused by dehydration, blood loss, urinary tract obstructions such as kidney stones or blood clots, low blood pressure, or heart disease. It ...
Free κ or λ light chains can aggregate with each other to cause extracellular amyloid deposits and a disease termed amyloidosis in which the deposits injure and ultimately lead to the failure of such organs as the kidney, heart, liver, stomach, and intestines; [15] these deposits can also cause peripheral and autonomic neuropathies. [1]
Monoclonal gammopathy, also known as paraproteinemia, is the presence of excessive amounts of myeloma protein or monoclonal gamma globulin in the blood. It is usually due to an underlying immunoproliferative disorder or hematologic neoplasms , especially multiple myeloma .