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Continuous HIV replication results in a state of generalized immune activation persisting throughout the chronic phase. [6] Immune activation, which is reflected by the increased activation state of immune cells and release of proinflammatory cytokines , results from the activity of several HIV gene products and the immune response to ongoing ...
In 2016, about 36.7 million people were living with HIV, and it resulted in 1 million deaths. [11] There were 300,000 fewer new HIV cases in 2016 than in 2015. [12] Most of those infected, live in sub-Saharan Africa. [4]
WHO Disease Staging System for HIV Infection and Disease was first produced in 1990 by the World Health Organization [1] and updated in 2007. [2] It is an approach for use in resource limited settings and is widely used in Africa and Asia and has been a useful research tool in studies of progression to symptomatic HIV disease .
HIV is a retrovirus that primarily infects components of the human immune system such as CD4 + T cells, macrophages and dendritic cells. It directly and indirectly destroys CD4 + T cells. [88] HIV is a member of the genus Lentivirus, [89] part of the family Retroviridae. [90] Lentiviruses share many morphological and biological characteristics.
The genome and proteins of HIV (human immunodeficiency virus) have been the subject of extensive research since the discovery of the virus in 1983. [1] [2] "In the search for the causative agent, it was initially believed that the virus was a form of the Human T-cell leukemia virus (HTLV), which was known at the time to affect the human immune system and cause certain leukemias.
HIV-associated neurocognitive disorders (HAND) are neurological disorders associated with HIV infection and AIDS. It is a syndrome of progressive deterioration of memory, cognition, behavior, and motor function in HIV-infected individuals during the late stages of the disease, when immunodeficiency is severe. [ 1 ]
Two types of HIV have been characterized: HIV-1 and HIV-2. HIV-1 is the virus that was initially discovered and termed both lymphadenopathy associated virus (LAV) and human T-lymphotropic virus 3 (HTLV-III). HIV-1 is more virulent and more infective than HIV-2, [20] and is the cause of the majority of HIV infections globally. The lower ...
The pathophysiology of HIV/AIDS involves, upon acquisition of the virus, that the virus replicates inside and kills T helper cells, which are required for almost all adaptive immune responses. There is an initial period of influenza-like illness , and then a latent, asymptomatic phase.