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Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. [14] It is used to treat anxiety (including anxiety disorders ), trouble sleeping , severe agitation , active seizures including status epilepticus , alcohol withdrawal , and chemotherapy-induced nausea and vomiting . [ 14 ]
Active metabolites are produced when a person's body metabolizes the drug into compounds that share a similar pharmacological profile to the parent compound and thus are relevant when calculating how long the pharmacological effects of a drug will last. Long-acting benzodiazepines with long-acting active metabolites, such as diazepam and ...
Effects of long-term benzodiazepine use may include disinhibition, impaired concentration and memory, depression, [19] [20] as well as sexual dysfunction. [6] [21] The long-term effects of benzodiazepines may differ from the adverse effects seen after acute administration of benzodiazepines. [22]
Lorazepam. Sold under the brand name Ativan®, lorazepam is a benzodiazepine used for anxiety in some cases. Oxazepam. As a generic and the brand names drugs Serax and Zaxopam, oxazepam is used to ...
Dizziness is often reported as being the withdrawal symptom that lasts the longest. A study testing neuropsychological factors found psychophysiological markers differing from normals, and concluded that protracted withdrawal syndrome was a genuine iatrogenic condition caused by the long-term use. [126]
A study by Phytomedicine showed that the herb can mitigate anxiety as much as pharmaceuticals like lorazepam or imipramine (the generics of Ativan and Tofranil) when taken twice a day over 60 days.
A number of studies have drawn an association between long-term benzodiazepine use and neuro-degenerative disease, particularly Alzheimer's disease. [150] It has been determined that long-term use of benzodiazepines is associated with increased dementia risk, even after controlling for protopathic bias. [13]
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