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The vaccine consists of live-attenuated recombinant vesicular stomatitis virus (VSV) and adenovirus serotype-5 (Ad5) expressing Ebola envelope glycoprotein. [3] The vaccine is targeted against the Makona variant of Ebola that was circulating in West Africa during the 2013-2016 outbreak.
Ebola vaccines are vaccines either approved or in development to prevent Ebola. As of 2022, there are only vaccines against the Zaire ebolavirus. The first vaccine to be approved in the United States was rVSV-ZEBOV in December 2019. [9] [10] It had been used extensively in the Kivu Ebola epidemic under a compassionate use protocol. [11]
Of the four disease-causing viruses in the genus Ebolavirus, Ebola virus (or the Zaire Ebola virus) is dangerous and is the virus responsible for the epidemic in Western Africa. [ 236 ] [ 237 ] Since the discovery of the viruses in 1976, Ebola virus disease has been confined to areas in Middle Africa, where it is native.
Story at a glance There have been 129 confirmed cases in the Ebola outbreak in Uganda and 37 deaths so far. The outbreak has reached the country’s capital city. Three experimental vaccine ...
In April 2019, following a large-scale ring-vaccination scheme in the DRC outbreak, the WHO published the preliminary results of its research, in association with the DRC's Institut National pour la Recherche Biomedicale, into the effectiveness of the ring vaccination program, stating that the rVSV-ZEBOV-GP vaccine had been 97.5% effective at stopping Ebola transmission, relative to no ...
The Ervebo vaccine, developed by Merck, is a single-dose vaccine. It works by using a modified virus to produce antibodies against Ebola, equipping the immune system to recognise and neutralise ...
A stockpile of half-a-million Ebola vaccine doses was established by Gavi and other global health partners in 2019 for use in outbreaks of haemorrhagic fever, which has an average fatality rate of ...
The 2014 Ebola outbreak – the deadliest in history – was primarily in West Africa but affected Sierra Leone the most, with nearly 4,000 deaths out of the more than 11,000 recorded globally. The country also lost 7% of its healthcare workforce to the outbreak.