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Elagolix is used in the treatment of moderate to severe pain associated with endometriosis in premenopausal women. [1] Endometriosis is a condition in which the endometrium, the inner lining of the uterus, grows outside of the uterus into surrounding tissues and causes symptoms such as pelvic pain and infertility. [13]
These agents, although efficacious, were associated with intolerable side effects. Danazol was first described for endometriosis in 1971 and became the main therapy in the 1970s and 1980s. [190] [191] [192] In the 1980s GnRH agonists gained prominence for the treatment of endometriosis and by the 1990s had become the most widely used therapy.
Relugolix acts as an GnRH antagonist, or an antagonist of the gonadotropin-releasing hormone receptor. [13] Estradiol is an estrogen, or an agonist of the estrogen receptors, whereas norethisterone acetate is a progestin (synthetic progestogen), or an agonist of the progesterone receptors. [14]
Endometriosis is a relatively common condition that causes pelvic pain, uncomfortable menstruation, and possible infertility. Learn more about the symptoms, causes, and treatment options.
A new study proposes that endometriosis could be diagnosed using a non-invasive stool sample to measure levels of a bacterial metabolite — 4-hydroxyindole — that is significantly lower in ...
The high endometrial activity of dienogest underlies its ability to stabilize the menstrual cycle when combined with either ethinylestradiol or estradiol valerate (which has lower relative effects on the uterus compared to ethinylestradiol) in birth control pills, and also its use in the treatment of endometriosis. [2]
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