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Hypotension, also known as low blood pressure, is a cardiovascular condition characterized by abnormally reduced blood pressure. [1] Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood [2] and is indicated by two numbers, the systolic blood pressure (the top number) and the diastolic blood pressure (the bottom number), which are the ...
Midodrine is a prodrug which forms the active metabolite, desglymidodrine, which is an α 1-adrenergic receptor agonist and exerts its actions via activation of α 1-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure.
Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke, heart failure, kidney failure and myocardial infarction. Evidence suggests that a reduction of blood pressure by 5 mmHg can decrease the risk of stroke by 34% and of ischaemic heart disease by 21%.
Blood in the urine; Pressure, or difficulty urinating; Unusual amounts of urination, usually in large quantities; A buildup of phosphates in the blood that diseased kidneys cannot filter out may cause: Itching; Bone damage; Nonunion in broken bones; Muscle cramps (caused by low levels of calcium which can be associated with hyperphosphatemia)
When blood pressure falls many physiological cascades commence in order to return the blood pressure to a more appropriate level. The blood pressure fall is detected by a decrease in blood flow and thus a decrease in glomerular filtration rate (GFR). Decrease in GFR is sensed as a decrease in Na + levels by the macula densa.
Diuretics, which lower blood pressure directly by causing the kidney to produce more urine. Beta-blockers, which slow down the heart and reduce the force of its contractions.
Blood tests are also used to assess kidney function. These include tests that are intended to directly measure the function of the kidneys, as well as tests that assess the function of the kidneys by looking for evidence of problems associated with abnormal function. One of the measures of kidney function is the glomerular filtration rate (GFR).
An antihypotensive, also known as vasopressor, is an agent that raises blood pressure by constricting blood vessels, thereby increasing systemic vascular resistance. This is different from inotropes which increase the force of cardiac contraction. Some substances do both (e.g. dopamine, dobutamine).