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Schematic of the Philadelphia chromosome formation The chromosomal defect in the Philadelphia chromosome is a reciprocal translocation , in which parts of two chromosomes, 9 and 22, swap places. The result is that a fusion gene is created by juxtaposing the ABL1 gene on chromosome 9 (region q34) to a part of the BCR (breakpoint cluster region ...
This image is a derivative work of the following images: File:Philadelphia_chromosome.jpg licensed with Cc-by-sa-2.5,2.0,1.0, Cc-by-sa-3.0-migrated, GFDL . 2007-01-16T00:35:50Z A Obeidat 401x211 (10412 Bytes) Philadelphia Chromosome Translocation
English: Scheme of a Chromosome. (1) Chromatid. One of the two identical parts of the chromosome after S phase. (2) Centromere. The point where the two chromatids touch, and where the microtubules attach. (3) Short (p) arm (4) Long (q) arm. In accordance with the display rules in Cytogenetics, the short arm is on top.
Schematic karyogram of a human as seen on G banding, with annotated bands and sub-bands.It is a graphical representation of the idealized human diploid karyotype. Each row is vertically aligned at centromere level.
The first fusion gene [1] was described in cancer cells in the early 1980s. The finding was based on the discovery in 1960 by Peter Nowell and David Hungerford in Philadelphia of a small abnormal marker chromosome in patients with chronic myeloid leukemia—the first consistent chromosome abnormality detected in a human malignancy, later designated the Philadelphia chromosome. [3]
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The schematic karyogram in this section is a graphical representation of the idealized karyotype. For each chromosome pair, the scale to the left shows the length in terms of million base pairs, and the scale to the right shows the designations of the bands and sub-bands.