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72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. [5] The MMP2 gene is located on chromosome 16 at position 12.2.
Matrix metalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium-dependent zinc-containing endopeptidases; [1] other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. [2]
The last part of the EC number is the serial number, identifying specific enzymes within a sub-subclass. 24 represents gelatinase A, which is a metalloproteinase that breaks down gelatin and collagen, while 35 represents gelatinase B, which hydrolyzes peptide bonds. [2]
4327 58223 Ensembl ENSG00000123342 ENSMUSG00000025355 UniProt Q99542 Q9JHI0 RefSeq (mRNA) NM_001032360 NM_001272101 NM_002429 NM_022790 NM_022792 NM_001164197 NM_021412 RefSeq (protein) NP_001259030 NP_002420 NP_001157669 NP_067387 Location (UCSC) Chr 12: 55.84 – 55.84 Mb Chr 10: 128.63 – 128.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Matrix metalloproteinase-19 (MMP-19 ...
n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a n/a Wikidata View/Edit Human Interstitial collagenase, also known as fibroblast collagenase and matrix metalloproteinase-1 (MMP-1), is an enzyme that in humans is encoded by the MMP1 gene. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3 ...
5-(spiropyrrolidin-5-yl)pyrimidinetrione is a compound named 848773-43-3 that is a potent MMP-2, MMP-9 and MMP-13 inhibitor that spares MMP-1 and TACE. By substituting 1,3,4-oxadiazol-2-yl heteroaryl at C-4’ of the diphenylether segment to accomplish MMP-13 selectivity over MT-1 MMP, made the
17395 Ensembl ENSG00000100985 ENSMUSG00000017737 UniProt P14780 P41245 RefSeq (mRNA) NM_004994 NM_013599 RefSeq (protein) NP_004985 NP_038627 Location (UCSC) Chr 20: 46.01 – 46.02 Mb Chr 2: 164.78 – 164.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Matrix metalloproteinase-9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a ...
4323 17387 Ensembl ENSG00000157227 ENSMUSG00000000957 UniProt P50281 P53690 RefSeq (mRNA) NM_004995 NM_008608 RefSeq (protein) NP_004986 NP_032634 Location (UCSC) Chr 14: 22.84 – 22.85 Mb Chr 14: 54.67 – 54.68 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Matrix metalloproteinase-14 is an enzyme that in humans is encoded by the MMP14 gene. Function Proteins of the matrix ...