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Metalloprotease inhibitors are cellular inhibitors of the Matrix metalloproteinases (MMPs). [1] MMPs belong to a family of zinc -dependent neutral endopeptidases . [ 2 ] These enzymes have the ability to break down connective tissue .
A matrix metalloproteinase inhibitor (INN stem –mastat [1]) inhibits matrix metalloproteinases. Because they inhibit cell migration, they have antiangiogenic effects. They are endogenous or exogenous. The most notorious endogenous metalloproteinases are tissue inhibitors of metalloproteinases, followed by cartilage-derived angiogenesis ...
Matrix metalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium-dependent zinc-containing endopeptidases; [1] other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. [2]
The glycoprotein is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti ...
Tissue inhibitors of metalloproteinases (TIMPs) are specific endogenous protease inhibitors to the matrix metalloproteinases. There are four TIMPs; TIMP1 , TIMP2 , TIMP3 and TIMP4 . [ 1 ] TIMP3 has been observed progressively downregulated in Human papillomavirus -positive neoplastic keratinocytes derived from uterine cervical preneoplastic ...
Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene. [5] [6] [7]This gene belongs to the tissue inhibitor of metalloproteinases gene family. . The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular mat
Stromelysin-1 also known as matrix metalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. The MMP3 gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [ 5 ]
Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene. [5] [6]This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM).