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The gastric folds (or gastric rugae) are coiled sections of tissue that exist in the mucosal and submucosal layers of the stomach. [1] They provide elasticity by allowing the stomach to expand when a bolus enters it. These folds stretch outward through the action of mechanoreceptors, which respond to the increase in pressure. [2]
The muscular layer consists of two layers of muscle, the inner and outer layer. [3] The muscle of the inner layer is arranged in circular rings around the tract, whereas the muscle of the outer layer is arranged longitudinally. The stomach has an extra layer, an inner oblique muscular layer. [1]
The inner part of the stomach wall is the gastric mucosa a mucous membrane that forms the lining of the stomach. the membrane consists of an outer layer of columnar epithelium, a lamina propria, and a thin layer of smooth muscle called the muscularis mucosa. Beneath the mucosa lies the submucosa, consisting of fibrous connective tissue. [17]
Rugae folds behind the anterior teeth in the hard palate of the mouth. In anatomy, rugae (sg.: ruga) are a series of ridges produced by folding of the wall of an organ. [1]In general, rugae are a biological feature found in many organisms, serving purposes such as increasing surface area, flexibility, or structural support.
Several types of endocrine cells are found in the gastric glands. The pyloric glands contain gastrin -producing cells ( G cells ); this hormone stimulates acid production from the parietal cells. Enterochromaffin-like cells (ECLs), found in the oxyntic glands release histamine , which also is a powerful stimulant of the acid secretion.
The mucus allows the acid at pH above 4 to penetrate lining, but below pH 4 (i.e. when acid is more concentrated) the acid cannot penetrate the mucus. This is called viscous fingering. [ 6 ] Thus the foveolar cells can pump out a lot of acid, but acid once in the lumen of the stomach is prevented from returning.
The stomach is a distensible organ and can normally expand to hold about one litre of food. [22] This expansion is enabled by a series of gastric folds in the inner walls of the stomach. The stomach of a newborn baby will only be able to expand to retain about 30 ml.
These are found in the lining sections of the gastrointestinal tract (inner lining of oesophagus, stomach, etc.) and may be brush bordered. Vertical section of a villus from the dog's small intestine.
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