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The shape of the T-tubule system is produced and maintained by a variety of proteins. The protein amphiphysin-2 is encoded by the gene BIN1 and is responsible for forming the structure of the T-tubule and ensuring that the appropriate proteins (in particular L-type calcium channels) are located within the T-tubule membrane. [9]
(This property holds because T tubules run perpendicular to the longitudinal axis of the muscle fiber.) In mammals, triads are typically located at the A-I junction ; [ 1 ] that is, the junction between the A and I bands of the sarcomere , which is the smallest unit of a muscle fiber.
A T-tubule surrounded by two terminal cisternae is called a triad. The terminal cisternae, along with the transverse tubules, are the mechanisms of transduction from a nervous impulse to an actual muscle contraction .
Cardiac and skeletal muscle cells contain structures called transverse tubules (T-tubules), which are extensions of the cell membrane that travel into the centre of the cell. T-tubules are closely associated with a specific region of the SR, known as the terminal cisternae in skeletal muscle, with a distance of roughly 12 nanometers, separating ...
In skeletal muscle, there is a very high concentration of L-type calcium channels, situated in the T-tubules. Muscle depolarization results in large gating currents, but anomalously low calcium flux, which is now explained by the very slow activation of the ionic currents.
The T-tubule is present in this area. The area between the Z-discs is further divided into two lighter colored bands at either end called the I-bands or Isotropic Bands, and a darker, grayish band in the middle called the A band or Anisotropic Bands.
These are known as transverse-tubules (t-tubules); which are also found in skeletal muscle cells and allow for the action potential to travel into the centre of the cell. [7] Special proteins called L-type calcium channels (also known as dihydropyridine receptors (DHPR)) are located on the t-tubule membrane , and are activated by the action ...
T tubule: transverse intracellular tubules invaginating from the cell membrane and surrounding the myofibrils of the T system of skeletal and cardiac muscle, serving as a pathway for the spread of electrical excitation within a muscle cell; Trachea: tubules forming the respiratory system of most insects and many arachnids