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Plaque exhibiting bacterial lawn with clearings made by Artharobacter phage GantcherGoblin.. The Actinobacteriophage database, more commonly known as PhagesDB, is an interactive, comprehensive, database-backed website that collects and shares information related to the discovery, characterization and genomics of viruses that typically infect Actinobacterial hosts.
Even engineered phages and induced artificial internalization of phages into mammalian cells do not result in phage propagation. [115] Natural transcytosis of unmodified phages, that is, uptake and internal transport to the other side of a cell, which was observed in human epithelial cells, did not result in phage propagation or cell damage. [116]
With lytic phages such as the T4 phage, bacterial cells are broken open (lysed) and destroyed after immediate replication of the virion. As soon as the cell is destroyed, the phage progeny can find new hosts to infect. [13] Lytic phages are more suitable for phage therapy. Some lytic phages undergo a phenomenon known as lysis inhibition, where ...
[8] [9] The molecular structure of Ff phages was determined using a number of physical techniques, especially X-ray fiber diffraction, [2] [6] solid-state NMR and cryo-electron microscopy. [10] The structures of the phage capsid and of some other phage proteins are available from the Protein Data Bank. [6]
Dating back to the 1940s and continuing today, T-even phages are considered the best studied model organisms. Model organisms are usually required to be simple with as few as five genes. Yet, T-even phages are in fact among the largest and highest complexity virus, in which these phage's genetic information is made up of around 300 genes.
Bacillus phage are classified based on their genome sequences. The total sequence length ranges from 7,826 (in phage pMC8) to 509,170 bp (in phage pHS181) with the GC content of these phage being an average of 38.25%.
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