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Drug-induced glomerular disease is not common but there are a few drugs that have been implicated. Glomerular lesions occur primarily through immune-mediated pathways rather than through direct drug toxicity. Heroin and Pamidronate are known to cause focal segmental glomerulosclerosis; Gold salts therapy can cause membranous nephropathy [4 ...
Brain and kidney damage (rare) Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. Ampicillin: Principen (discontinued) Azlocillin: Dicloxacillin: Dynapen (discontinued) Flucloxacillin: Floxapen (Sold to European generics Actavis Group) Mezlocillin: Mezlin (discontinued ...
Imipenem is the active antibiotic agent and works by interfering with their ability to form cell walls, so the bacteria break up and die. Imipenem is rapidly degraded by the renal enzyme dehydropeptidase if administered alone (making it less effective); the metabolites can cause kidney damage. [9]
What causes kidney disease? The most common causes of CKD are high blood pressure and diabetes, "which damage the small blood vessels and filtering units in the kidneys over time," says Nagata ...
Interstitial nephritis is uncommon (<1% incidence) in patients without any symptoms but occurs in about 10-15% of hospitalized patients with acute kidney injury of unknown cause. [2] While it can occur in patients of all ages, it is more common in elderly patients, perhaps due to increased exposure to drugs and other triggering causes. [2]
Kidney damage is a problem in 10–25% of people who receive aminoglycosides, and gentamicin is one of the most nephrotoxic drugs of this class. [21] Oftentimes, acute nephrotoxicity is reversible, but it may be fatal. [14]