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To ensure proper temporal differentiation as well as correct quantities of glial cell formation, gliogenesis is subjected to stringent regulatory mechanisms. Proneural factors are expressed in high concentrations during times in which glial cells are not to form or neuron development is needed.
Glial cells known as astrocytes enlarge and proliferate to form a scar and produce inhibitory molecules that inhibit regrowth of a damaged or severed axon. In the peripheral nervous system (PNS), glial cells known as Schwann cells (or also as neuri-lemmocytes) promote repair. After axonal injury, Schwann cells regress to an earlier ...
Neuronal precursor cells proliferate in the ventricular zone of the developing neocortex, where the principal neural stem cell is the radial glial cell. The first postmitotic cells must leave the stem cell niche and migrate outward to form the preplate, which is destined to become Cajal–Retzius cells and subplate neurons. These cells do so by ...
Most neurotrophic factors belong to one of three families: (1) neurotrophins, (2) glial cell-line derived neurotrophic factor family ligands (GFLs), and (3) neuropoietic cytokines. [4] Each family has its own distinct cell signaling mechanisms, although the cellular responses elicited often do overlap. [4]
The GDNF family of ligands (GFL) consists of four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). GFLs have been shown to play a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration.
The two main types of cells in the brain are neurons, also known as nerve cells, and glial cells, also known as neuroglia. [1] There are many types of neuron, and several types of glial cell. Neurons are the excitable cells of the brain that function by communicating with other neurons and interneurons (via synapses ), in neural circuits and ...
This increased energy consumption is reflected in glial and local capillary vasculation that provides synapses with extra energy. Glial cell numbers per neuron increase 12–14% [5] [7] The direct apposition area of glial cells with synapses expands by 19% [21] The volume of glial cell nuclei for each synapse is higher by 37.5% [18]
The cells of the brain include neurons and supportive glial cells. There are more than 86 billion neurons in the brain, and a more or less equal number of other cells. Brain activity is made possible by the interconnections of neurons and their release of neurotransmitters in response to nerve impulses.