Search results
Results From The WOW.Com Content Network
Trypanosomiasis could, in future be prevented by genetically altering the tsetse fly. As the tsetse fly is the main vector of transmission, making the fly immune to the disease by altering its genome could be the main component in an effort to eradicate the disease.
T. brucei, which causes sleeping sickness in humans and nagana in cattle; T. cruzi, which causes Chagas disease in humans; Trypanosoma culicavium, which infects birds and mosquitoes; T. congolense, which causes nagana in ruminant livestock, horses and a wide range of wildlife; T. equinum, in South American horses, transmitted via Tabanidae,
Its cell membrane (called pellicle) encloses the cell organelles, including the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, and ribosomes. In addition, there is an unusual organelle called the kinetoplast , which is a complex of thousands of interlinked circles of mitochondrial DNA known as mini- and maxicircles. [ 60 ]
African trypanosomiasis is an insect-borne parasitic infection of humans and other animals. [3]Human African trypanosomiasis (HAT), also known as African sleeping sickness or simply sleeping sickness, is caused by the species Trypanosoma brucei. [3]
Chagas disease is caused by infection with the protozoan parasite T. cruzi, which is typically introduced into humans through the bite of triatomine bugs, also called "kissing bugs". [4] When the insect defecates at the bite site, motile T. cruzi forms called trypomastigotes enter the bloodstream and invade various host cells. [5]
The three major human diseases caused by trypanosomatids are; African trypanosomiasis (sleeping sickness, caused by Trypanosoma brucei and transmitted by tsetse flies [3]), South American trypanosomiasis (Chagas disease, caused by T. cruzi and transmitted by triatomine bugs), and leishmaniasis (a set of trypanosomal diseases caused by various species of Leishmania transmitted by sandflies [4]).
Animal trypanosomiasis, also known as nagana and nagana pest, or sleeping sickness, is a disease of vertebrates. The disease is caused by trypanosomes of several species in the genus Trypanosoma such as T. brucei. T. vivax causes nagana mainly in West Africa, although it has spread to South America. [1]
Synthesis of Trypanothione. The main function of trypanothione synthase is to use the free energy generated from ATP hydrolysis to conjugate glutathione and spermidine to form the intermediate of glutathionylspermidine and then the final product of trypanothione. [5] It also catalyzes the reverse reaction as well, albeit at a much lower rate.