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One common way in which trypanosomiasis can be diagnosed in humans is through the detection of antibodies against trypanosomes made by host organisms. [6] One commonly used antibody test which operated based on this principle is the card agglutination test, C.A.T.T. for T. gambiense. [6] [7] In this test, reagent is mixed with blood and shaken.
They are generally found in the intestine of their invertebrate host, but normally occupy the bloodstream or an intracellular environment in the vertebrate host. Trypanosomes infect a variety of hosts and cause various diseases, including the fatal human diseases sleeping sickness , caused by Trypanosoma brucei , [ 4 ] and Chagas disease ...
The first is a parasite of non-human mammals and causes nagana, while the latter two are zoonotic infecting both humans and animals and cause African trypanosomiasis. T. brucei is transmitted between mammal hosts by an insect vector belonging to different species of tsetse fly (Glossina). Transmission occurs by biting during the insect's blood ...
African trypanosomiasis is an insect-borne parasitic infection of humans and other animals. [3]Human African trypanosomiasis (HAT), also known as African sleeping sickness or simply sleeping sickness, is caused by the species Trypanosoma brucei. [3]
Chagas disease is caused by infection with the protozoan parasite T. cruzi, which is typically introduced into humans through the bite of triatomine bugs, also called "kissing bugs". [4] When the insect defecates at the bite site, motile T. cruzi forms called trypomastigotes enter the bloodstream and invade various host cells. [5]
The three major human diseases caused by trypanosomatids are; African trypanosomiasis (sleeping sickness, caused by Trypanosoma brucei and transmitted by tsetse flies [3]), South American trypanosomiasis (Chagas disease, caused by T. cruzi and transmitted by triatomine bugs), and leishmaniasis (a set of trypanosomal diseases caused by various species of Leishmania transmitted by sandflies [4]).
Animal trypanosomiasis, also known as nagana and nagana pest, or sleeping sickness, is a disease of vertebrates. The disease is caused by trypanosomes of several species in the genus Trypanosoma such as T. brucei. T. vivax causes nagana mainly in West Africa, although it has spread to South America. [1]
Synthesis of Trypanothione. The main function of trypanothione synthase is to use the free energy generated from ATP hydrolysis to conjugate glutathione and spermidine to form the intermediate of glutathionylspermidine and then the final product of trypanothione. [5] It also catalyzes the reverse reaction as well, albeit at a much lower rate.