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In ICP8, the herpes simplex virus (HSV-1) single-strand DNA-binding protein (ssDNA-binding protein (SSB)), the head consists of the eight alpha helices.The front side of the neck region consists of a five-stranded beta-sheet and two alpha helices, whereas the back side is a three-stranded beta-sheet The shoulder part of the N-terminal domain contains an alpha-helical and beta-sheet region. [1]
Replication protein A (RPA) is the major protein that binds to single-stranded DNA (ssDNA) in eukaryotic cells. [1] [2] In vitro, RPA shows a much higher affinity for ssDNA than RNA or double-stranded DNA. [3] RPA is required in replication, recombination and repair processes such as nucleotide excision repair and homologous recombination.
Single-stranded DNA is produced during all aspects of DNA metabolism: replication, recombination, and repair. As well as stabilizing this single-stranded DNA, SSB proteins bind to and modulate the function of numerous proteins involved in all of these processes. Active E. coli SSB is composed of four identical 19 kDa subunits. Binding of single ...
A distinct group of DNA-binding proteins are the DNA-binding proteins that specifically bind single-stranded DNA. In humans, replication protein A is the best-understood member of this family and is used in processes where the double helix is separated, including DNA replication, recombination and DNA repair. [18]
Nucleic acid binding protein 1 is a protein that in humans is encoded by the NABP1 gene. [5] Function. Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A ...
From there, messenger RNA (mRNA) that encodes the viral initiator protein is transcribed and translated to synthesize the protein. The initiator protein commences RHR by binding to and nicking the genome in a region adjacent to a hairpin called the origin and establishing a replication fork with its helicase activity. Nicking leads to the ...