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ETS1 binds with DNA-dependent protein kinase (DNA-PK) [where the DNA-PK complex is made up of DNA-PKcs and DNA repair Ku (protein), and where Ku itself is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5)]. [17] ETS1 interaction with DNA-PK phosphorylates ETS1. [17] Such phosphorylation of ETS1 alters its target gene repertoire. [18]
There are 28 genes in humans, [4] 27 in the mouse, 10 in Caenorhabditis elegans and 9 in Drosophila. The founding member of this family was identified as a gene transduced by the leukemia virus, E26. The members of the family have been implicated in the development of different tissues as well as cancer progression.
Transcription factor MafB also known as V-maf musculoaponeurotic fibrosarcoma oncogene homolog B is a protein that in humans is encoded by the MAFB gene. This gene maps to chromosome 20q11.2-q13.1, consists of a single exon and spans around 3 kb. [5] [6]
MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene. [5] [6]
12914 Ensembl ENSG00000005339 ENSMUSG00000022521 UniProt Q92793 P45481 RefSeq (mRNA) NM_001079846 NM_004380 NM_001025432 RefSeq (protein) NP_001073315 NP_004371 n/a Location (UCSC) Chr 16: 3.73 – 3.88 Mb Chr 16: 3.9 – 4.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CREB-binding protein, also known as CREBBP or CBP or KAT3A, (where CREB is cAMP response element-binding ...
SHOC1 in humans has at least 6 alternate isoforms, with at least 10 more predicted. [8] The primarily used sequence in humans is C9orf84 Isoform 1. This isoform is 1444 aa long, contains 26 exons, has a predicted molecular weight of 165.190 kDa, and a predicted pI of 5.10. [9] SHOC1 has been shown to undergo phosphorylation. [10]
Transforming growth factor-β (TGF-β) principally relays its effects through the Smad pathway however, accumulating evidence indicate that alternative signalling routes are also employed by this pleiotropic cytokine.
A neuronal lineage marker is an endogenous tag that is expressed in different cells along neurogenesis and differentiated cells such as neurons.It allows detection and identification of cells by using different techniques.