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Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations, including roundworm, hookworm, whipworm, threadworm (pinworm), and the intestinal form of trichinosis prior to its spread into the tissues beyond the digestive tract.
Mansonella perstans is a filarial (arthropod-borne) nematode (roundworm), transmitted by tiny blood-sucking flies called midges. [1] Mansonella perstans is one of two filarial nematodes that causes serous cavity filariasis in humans. The other filarial nematode is Mansonella ozzardi.
Pyrantel pamoate – effective against most parasitic nematodes of the GIT; Macrocyclic lactones are glutamate-gated chloride channel agonists, [8] and include: Avermectins (including ivermectin and moxidectin) - effective against most common intestinal worms, except tapeworms, for which praziquantel is commonly used in conjunction for mass ...
Mebendazole appeared more active than DEC in eliminating the infection, and had comparable overall responses. Thiabendazole evidenced a small, but significant activity against the infection. A combination of treatments, DEC plus mebendazole, was much more effective than single drug doses.
Broad-spectrum benzimidazoles (such as albendazole and mebendazole) are the first line treatment of intestinal roundworm and tapeworm infections. Macrocyclic lactones (such as ivermectin ) are effective against adult and migrating larval stages of nematodes.
Soil-transmitted helminths are typically from the following families of nematodes, namely: [citation needed] Roundworms (family Ascarididae), e.g. Ascaris lumbricoides; Whipworms (family Trichuridae), e.g. Trichuris trichiura; Hookworms (family Ancylostomatidae), e.g. Ancylostoma duodenale and Necator americanus
Those recommended by the World Health Organization for ascariasis are: albendazole, mebendazole, levamisole and pyrantel pamoate. [2] Single-dose of albendazole, mebendazole, and ivermectin are effective against ascariasis. They are effective at removing parasites and eggs from the intestines. [34]
The most efficacious dose in all nematode and parasitic infections is 200 μg/kg of ivermectin. [6] There has also been other various anthelminthic drugs used, such as mebendazole, levamisole, albendazole and thiabendazole. [2] [7] In worst-case scenarios, surgery may be necessary to remove nematodes from the abdomen or chest. However, mild ...