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Trazodone is a 5-HT 1A receptor partial agonist similarly to buspirone and tandospirone but with comparatively greater intrinsic activity. [90] [107] [108] A range of weak affinities (K i) have been reported for trazodone at the human histamine H 1 receptor, including 220 nM, [90] 350 nM, [105] 500 nM, [109] and 1,100 nM. [94]
"Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose. Benzodiazepines generally share the same pharmacological properties, such as anxiolytic, sedative, hypnotic, skeletal muscle relaxant, amnesic, and anticonvulsant effects. Variation in potency of certain effects may exist amongst individual ...
Most but not all values are for human proteins. These drugs act as antagonists or inverse agonists of the 5-HT 2A , α 1 -adrenergic, and H 1 receptors, as partial agonists of the 5-HT 1A receptor, [ 3 ] and as inhibitors of the transporters. mCPP is an antagonist of the 5-HT 2B receptor, an agonist of the 5-HT 1A , [ 3 ] 5-HT 2C , and 5-HT 3 ...
This is a list of adverse effects of the antidepressant trazodone, sorted by frequency of occurrence. [1] [2] [3] Very common.
Pindolol, a beta blocker and serotonin 5-HT 1A receptor antagonist, has been reported to potentiate the hallucinogenic effects of DMT by 2- to 3-fold in humans. [33] [34] High-dose nicotinic acid (niacin, a B 3 vitamer) was reported to reduce and block the effects of LSD in one early clinical study.
An atypical antidepressant is any antidepressant medication that acts in a manner that is different from that of most other antidepressants. Atypical antidepressants include agomelatine, bupropion, iprindole, mianserin, mirtazapine, nefazodone, opipramol, tianeptine, and trazodone.