Search results
Results From The WOW.Com Content Network
A transcription bubble is a molecular structure formed during DNA transcription when a limited portion of the DNA double helix is unwound. The size of a transcription bubble ranges from 12 to 14 base pairs. A transcription bubble is formed when the RNA polymerase enzyme binds to a promoter and causes two DNA strands to detach. [1]
RNA polymerase, assisted by one or more general transcription factors, then selects a transcription start site in the transcription bubble, binds to an initiating NTP and an extending NTP (or a short RNA primer and an extending NTP) complementary to the transcription start site sequence, and catalyzes bond formation to yield an initial RNA product.
Eukaryotic transcription is the elaborate process that eukaryotic cells use to copy ... Location Product RNA ... Meanwhile, the transcription bubble collapses down to ...
The DNA double helix is rewound by RNA polymerase at the rear of the transcription bubble. [3] Like how two adjacent zippers work, when pulled together, they unzip and rezip as they proceed in a particular direction. Various factors can cause double-stranded DNA to break; thus, reorder genes or cause cell death. [4]
The Pribnow box has a function similar to the TATA box that occurs in promoters in eukaryotes and archaea: it is recognized and bound by a subunit of RNA polymerase during initiation of transcription. [3] This region of the DNA is also the first place where base pairs separate during prokaryotic transcription to allow access to the template strand.
SNP rs114543781, 284 bases upstream is present where transcription factor HOXB13 is predicted to bind. This transcription factor is invovled in the developmental regulatory system that provides cells with positional identities along the anterior-posterior axis. SNP rs74343303, 193 bases upstream also interferes with FOXD3 binding.
The amount of transcription factories found per nucleus appears to be determined by cell type, species and the type of measurement. Cultured mouse embryonic fibroblasts have been found to have roughly 1500 factories through immunofluorescence detection of RNAP II however cells taken from different tissues of the same mouse group had between 100 ...
Transcription preinitiation complex, represented by the central cluster of proteins, causes RNA polymerase to bind to target DNA site. The PIC is able to bind both the promoter sequence near the gene to be transcribed and an enhancer sequence in a different part of the genome, allowing enhancer sequences to regulate a gene distant from it.