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Moxetumomab pasudotox, sold under the brand name Lumoxiti, is an anti-CD22 immunotoxin medication for the treatment of adults with relapsed or refractory hairy cell leukemia (HCL) who have received at least two prior systemic therapies, including treatment with a purine nucleoside analog.
CAT-3888 or BL22 is an anti-CD22 immunotoxin and in 2015 completed a Phase I clinical (human) trial for the treatment of hairy cell leukemia [1] at the NIH in the U.S. Technically, CAT-3888 is an anti-CD22 immunotoxin fusion protein between a murine anti-CD22 disulfide-linked Fv (dsFv) antibody fragment and an edited copy of bacterial ...
Hairy cell leukemia is an uncommon hematological malignancy characterized by an accumulation of abnormal B lymphocytes. [1] The incidence of hairy cell leukemia (HCL) is 0.28-0.30 cases per 100,000 people in Europe and the United States and the prevalence is 3 cases per 100,000 in Europe with a lower prevalence in Asia, Africa and the Middle East.
Cladribine is used as a first- and second-line treatment for symptomatic hairy cell leukemia and for B-cell chronic lymphocytic leukaemia, and is administered by intravenous or subcutaneous infusion. [ 9 ] [ 14 ] Some investigators have used the parenteral formulation orally to treat patients with hairy cell leukemia.
non-seminomatous germ cell tumors PEI cisplatin, etoposide, ifosfamide: small-cell lung carcinoma platin + taxane [5] cisplatin/carboplatin, paclitaxel/docetaxel: ovarian cancer: POMP 6-mercaptopurine (Purinethol), vincristine (Oncovin), methotrexate, and prednisone: acute adult leukemia [6] ProMACE-MOPP
The myeloid cell line normally produces granulocytes, erythrocytes, thrombocytes, macrophages and mast cells; the lymphoid cell line produces B, T, NK and plasma cells. Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases ...
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