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Familial hypertriglyceridemia (type IV familial dyslipidemia) is a genetic disorder characterized by the liver overproducing very-low-density lipoproteins (VLDL). As a result, an affected individual will have an excessive number of VLDL and triglycerides on a lipid profile.
Familial hypertriglyceridemia is an autosomal dominant condition occurring in approximately 1% of the population. [27] This form is due to high triglyceride level. Other lipoprotein levels are typically within the normal reference range or slightly increased. [ 28 ]
Hypertriglyceridemia is the presence of high amounts of triglycerides in the blood.Triglycerides are the most abundant fatty molecule in most organisms. Hypertriglyceridemia occurs in various physiologic conditions and in various diseases, and high triglyceride levels are associated with atherosclerosis, even in the absence of hypercholesterolemia (high cholesterol levels) and predispose to ...
Familial hypercholesterolemia is a specific form of hypercholesterolemia due to a defect on chromosome 19 (19p13.1-13.3). Hyperglyceridemia: glycerides. Hypertriglyceridemia: triglycerides; Hypolipidemia. Hypocholesterolemia: cholesterol; Lipoprotein: Hyperlipoproteinemia: lipoproteins (usually LDL unless otherwise specified) Honemia: chylomicrons
Familial combined hyperlipidemia (FCH) is the familial occurrence of this disorder, probably caused by decreased LDL receptor and increased ApoB. Acquired combined hyperlipidemia is extremely common in patients who have other diseases from the metabolic syndrome ("syndrome X", incorporating diabetes mellitus type II , hypertension , central ...
Familial hypercholesterolemia (FH) is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein cholesterol (LDL cholesterol), in the blood and early cardiovascular diseases.
Familial LPL deficiency should be considered in anyone with severe hypertriglyceridemia and the chylomicronemia syndrome. The absence of secondary causes of severe hypertriglyceridemia (like e.g. diabetes, alcohol, estrogen -, glucocorticoid -, antidepressant - or isotretinoin -therapy, certain antihypertensive agents , and paraproteinemic ...
Lipaemia retinalis occurs commonly with familial hypertriglyceridaemia, and rarely with combined hypertriglyceridaemia. [4] Although serum triglyceride levels above 1000 mg / dL can cause eye symptoms such as xanthoma , xanthelasma and arcus senilis , lipaemia retinalis is most commonly seen when the triglyceride level is above 1500 mg / dL. [ 7 ]