Search results
Results From The WOW.Com Content Network
NADPH oxidase (nicotinamide adenine dinucleotide phosphate oxidase) is a membrane-bound enzyme complex that faces the extracellular space. It can be found in the plasma membrane as well as in the membranes of phagosomes used by neutrophil white blood cells to engulf microorganisms.
After activation, the regulatory subunits p67phox, p47phox, p40phox and a GTPase, typically Rac, are recruited to the complex to form NADPH oxidase on the plasma membrane or phagosomal membrane. [7] Nox2 itself is composed of an N-terminal transmembrane domain that binds two heme groups, and a C-terminal domain that is able to bind to FAD and ...
50508 224480 Ensembl ENSG00000074771 ENSMUSG00000023802 UniProt Q9HBY0 Q672J9 RefSeq (mRNA) NM_015718 NM_198958 RefSeq (protein) NP_056533 NP_945196 Location (UCSC) Chr 6: 155.4 – 155.46 Mb Chr 17: 3.69 – 3.75 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse NADPH oxidase 3 is an enzyme that in humans is encoded by the NOX3 gene. Function NADPH oxidases, such as NOX3, are plasma ...
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP [1] [2] or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source'). NADPH is the reduced form, whereas NADP + is the ...
NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases. [5] Function
NADPH oxidase 1 is an enzyme that in humans is encoded by the NOX1 gene. [5] NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Two transcript variants encoding different isoforms have been found for this gene. [6]
71893 Ensembl ENSG00000196408 ENSMUSG00000019320 UniProt Q8NFA2 Q8VCM2 RefSeq (mRNA) NM_001267721 NM_144603 NM_172167 NM_172168 NM_027988 NM_001357836 RefSeq (protein) NP_001254650 NP_653204 NP_751907 NP_751908 NP_082264 NP_001344765 Location (UCSC) Chr 16: 1.98 – 1.98 Mb Chr 17: 24.92 – 24.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse NADPH oxidase organizer 1 is an enzyme ...
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome .