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Tamsulosin is a selective α 1 receptor antagonist that has preferential selectivity for the α 1A receptor in the prostate versus the α 1B receptor in the blood vessels. [ 25 ] When alpha 1 receptors in the bladder neck, prostate, ureter, and urethra are blocked, a relaxation in smooth muscle tissue results. [ 16 ]
Naftopidil and tamsulosin may have similar levels of unwanted sexual side effects but fewer unwanted side effects than silodosin. [58] Tamsulosin and silodosin are selective α1 receptor blockers that preferentially bind to the α1A receptor in the prostate instead of the α1B receptor in the blood vessels.
BPH is normally initially treated medically through alpha antagonists such as tamsulosin, or 5-alpha-reductase inhibitors such as finasteride and dutasteride.If medical treatment does not reduce a patient's urinary symptoms, a TURP may be considered following a careful examination of the prostate or bladder through a cystoscope.
These include tamsulosin to relax smooth muscles in the bladder neck, and finasteride and dutasteride to decrease prostate enlargement. The drugs only work for mild cases of BPH but also have mild side effects.
Tamsulosin: Flomax A blocker that has slight selectivity for α 1 receptors. [2] Relaxation of prostatic smooth muscle. [2] Benign prostatic hyperplasia [2] [11] Orthostatic hypotension [2] Yohimbine: Yocon Blocks α 2 receptor, and increases norepinephrine release, thus increasing CNS activity. [2] Raises blood pressure and heart rate. [2 ...
An enlarged prostate is common in older men and typically carries symptoms of lower urinary tract problems, which can become bladder problems over time. Tadalafil is typically taken daily for BPH.