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Reserpine is a drug that is used for the treatment of high blood pressure, usually in combination with a thiazide diuretic or vasodilator. [1] Large clinical trials have shown that combined treatment with reserpine plus a thiazide diuretic reduces mortality of people with hypertension.
Syrosingopine is a drug, derived from reserpine. It is used (since about 1960) to treat hypertension. [1] [2] Research
Some indirect anti-adrenergics are rarely used in treatment-resistant hypertension: guanethidine – replaces norepinephrine in vesicles, decreasing its tonic release; mecamylamine – antinicotinic and ganglion blocker; reserpine – indirect via irreversible VMAT inhibition
Reserpine, a monoamine-depleting agent. Monoamine-depleting agents are a group of drugs which reversibly deplete one or more of the monoamine neurotransmitters – serotonin, dopamine, and norepinephrine. [1] [2] One mechanism by which these agents act is by inhibiting reuptake by the vesicular monoamine transporters, VMAT1 and VMAT2.
The treatment for hypertension will depend on how high your blood pressure is and what’s causing it. For example, elevated blood pressure and hypertension stage 1 may require some lifestyle changes.
Guidelines for treating resistant hypertension have been published in the UK [45] and US. [46] It has been proposed that a proportion of resistant hypertension may be the result of chronic high activity of the autonomic nervous system, known as "neurogenic hypertension". [47] Low adherence to treatment is an important cause of resistant ...