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The anti-TNF-α monoclonal antibody infliximab is a major biological therapy for inflammatory bowel disease. Biological therapy, the use of medications called biopharmaceuticals or biologics that are tailored to specifically target an immune or genetic mediator of disease, plays a major role in the treatment of inflammatory bowel disease. [1]
Before using biologics to treat psoriasis, treatment with topical moisturizers or steroids, or light therapy may provide relief. Other drugs which may provide relief include acitretin , ciclosporin , and methotrexate , but since these drugs have their own major side effects, doctors and patients should discuss whether to try one of these or a ...
Human monoclonal antibodies are identified with the suffix "-umab". They originate from a human. [7] An example of a human monoclonal antibody is ustekinumab, which treats psoriasis. [6] During the early stages of the COVID-19 pandemic, reliable treatment options had not yet been found or approved. In reaction, convalescent blood plasma was ...
Immunoglobulin therapy is the use of a mixture of antibodies (normal human immunoglobulin) to treat several health conditions. [13] [14] These conditions include primary immunodeficiency, immune thrombocytopenic purpura, chronic inflammatory demyelinating polyneuropathy, Kawasaki disease, certain cases of HIV/AIDS and measles, Guillain–Barré syndrome, and certain other infections when a ...
A representation of the cholera epidemic of the 19th century. For thousands of years mankind has been intrigued with the causes of disease and the concept of immunity. The prehistoric view was that disease was caused by supernatural forces, and that illness was a form of theurgic punishment for "bad deeds" or "evil thoughts" visited upon the soul by the gods or by one's enemies. [8]
Immunotherapy for the treatment of cancer is an active area of medical research. [141] The main response of the immune system to tumors is to destroy the abnormal cells using killer T cells, sometimes with the assistance of helper T cells. [138] [142] Tumor antigens are presented on MHC class I molecules in a similar way to viral antigens.
The advantage of active monoclonal antibody therapy is the fact that the immune system will produce antibodies long-term, with only a short-term drug administration to induce this response. However, the immune response to certain antigens may be inadequate, especially in the elderly.
A possible definition of Immunopathology is how the foreign antigens cause the immune system to have a response or problems that can arise from an organism's own immune response on itself. There are certain problems or faults in the immune system that can lead to more serious illness or disease.