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Janeway lesions are rare, non-tender, small erythematous or haemorrhagic macular, papular or nodular lesions on the palms or soles only a few millimeters in diameter that are associated with infective endocarditis and often indistinguishable from Osler's nodes.
Roth's spots, also known as Litten spots or the Litten sign, [1] are non-specific red lesions with white or pale centres, seen on the retina of the eye and although traditionally associated with infective endocarditis, can occur in a number of other conditions including hypertension, diabetes, collagen vascular disease, extreme hypoxia, leukemia and HIV.
The resulting inflammatory response leads to swelling, redness, and pain that characterize these lesions. The nodes are commonly indicative of subacute bacterial endocarditis. [3] 10–25% of endocarditis patients will have Osler's nodes. [4] Other signs of endocarditis include Roth's spots and Janeway lesions. The latter, which also occur on ...
Signs and symptoms include fever, chills, sweating, malaise, weakness, anorexia, weight loss, splenomegaly, flu-like feeling, cardiac murmur, heart failure, petechia (red spots on the skin), Osler's nodes (subcutaneous nodules found on hands and feet), Janeway lesions (nodular lesions on palms and soles), and Roth's spots (retinal hemorrhages).
Vascular phenomena: arterial emboli, pulmonary infarcts, Janeway lesions, conjunctival hemorrhage Immunological phenomena: glomerulonephritis , Osler's nodes , Roth's spots , Rheumatoid factor Microbiologic evidence: Positive blood culture (that doesn't meet a major criterion) or serologic evidence of infection with organism consistent with IE ...
Janeway lesion: Theodore Caldwell Janeway: cardiology: infective endocarditis: palmar or plantar erythematous or haemorrhagic papules Jendrassik maneuver: Ernő Jendrassik: neurology: hyporeflexia: compares patellar reflex w/ and w/o distraction Jobe's relocation test Christopher Jobe orthopedics Joffroy's sign: Alexis Joffroy: endocrinology
Janeway lesion; Osler's node; At the nails Splinter hemorrhage and Quincke's pulsation should be looked for as well as any deformity of the nail such as Beau's lines, clubbing or peripheral cyanosis. Inspect the head for: Cheeks for the malar flush of mitral stenosis. The eyes for corneal arcus and surrounding tissue for xanthalasma.
Theodore C. Janeway was born in New York City, the son of Edward G. Janeway, M.D. Edward Janeway was himself a prominent clinician and pathologist who is credited with the identification of non-tender lesions on the palms or soles of individuals with endocarditis, later called Janeway lesions in his honor.