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RAS Mutations & Treatment Options
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PDAC Remains Highly Lethal
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Pancreatic cancer is among the most deadly forms of cancer globally, with one of the lowest survival rates. In 2015, pancreatic cancers of all types resulted in 411,600 deaths globally. [8] Pancreatic cancer is the fifth-most-common cause of death from cancer in the United Kingdom, [19] and the third most-common in the United States. [20]
A pancreatic tumor is an abnormal growth in the pancreas. [1] In adults, almost 90% are pancreatic cancer and a few are benign. [1] Pancreatic tumors are rare in children. [1] Classification is based on cellular differentiation (ductal, acinar, neuroendocrine, other) and gross appearance (intraductal, cystic, solid). [1]
It is usually solitary and found in the body or tail of the pancreas, and may be associated with von Hippel–Lindau syndrome. [2] In contrast to some of the other cyst-forming tumors of the pancreas (such as the intraductal papillary mucinous neoplasm and the pancreatic mucinous cystadenoma), serous cystic neoplasms are almost always entirely ...
Pancreatic neuroendocrine tumours (PanNETs, PETs, or PNETs), often referred to as "islet cell tumours", [1] [2] or "pancreatic endocrine tumours" [3] [4] are neuroendocrine neoplasms that arise from cells of the endocrine and nervous system within the pancreas.
The pancreas narrows towards the tail, which sits near to the spleen. [7] It is usually between 1.3–3.5 cm (0.51–1.38 in) long, and sits between the layers of the ligament between the spleen and the left kidney. The splenic artery and vein, which also passes behind the body of the pancreas, pass behind the tail of the pancreas. [7]
While most pancreatic cancer strikes people in their 70s, one doctor says, "Sometimes patients are in their 40s, 30s and even 20s." In women, a pronounced increase in numbers has been observed ...
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