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Because bilirubin is a skin irritant, jaundice is commonly associated with severe itchiness. [16] [17] Eye conjunctiva has a particularly high affinity for bilirubin deposition due to high elastin content. Slight increases in serum bilirubin can, therefore, be detected early on by observing the yellowing of sclerae.
Mechanism of competitive inhibition. Certain drugs share the same plasma protein, bilirubin, for transportation in the bloodstream. When drug concentration is high, they may outcompete bilirubin for binding. Bilirubin is displaced out so serum unconjugated bilirubin levels rise, resulting in unconjugated hyperbilirubinemia.
In the anatomy of the eye, the conjunctiva (pl.: conjunctivae) is a thin mucous membrane that lines the inside of the eyelids and covers the sclera (the white of the eye). [1] It is composed of non-keratinized, stratified squamous epithelium with goblet cells , stratified columnar epithelium and stratified cuboidal epithelium (depending on the ...
A red eye is an eye that appears red due to illness or injury. It is usually injection and prominence of the superficial blood vessels of the conjunctiva, which may be caused by disorders of these or adjacent structures. Conjunctivitis and subconjunctival hemorrhage are two of the less serious but more common causes.
Gilbert syndrome is a phenotypic effect, mostly associated with increased blood bilirubin levels, but also sometimes characterized by mild jaundice due to increased unconjugated bilirubin, that arises from several different genotypic variants of the gene for the enzyme responsible for changing bilirubin to the conjugated form.
This article was reviewed by Craig Primack, MD, FACP, FAAP, FOMA. Ah, New Year’s Day. You can set goals at any time of year, of course, but the new year provides that extra rush of motivation.
Meet the experts: Purvi Parikh, M.D., an allergist with Allergy & Asthma Network; Kanwar Kelley, M.D., otolaryngologist (ENT) and co-founder and CEO of Side Health; Phillip Purnell, M.D., Ph.D ...
"Just as you can develop melanoma on your skin, you can also develop it inside your eye or on your conjunctiva. Although it is the most common eye cancer in adults, ocular melanoma is very rare ...