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  2. Substantia nigra - Wikipedia

    en.wikipedia.org/wiki/Substantia_nigra

    Levodopa can cross the blood–brain barrier and increases dopamine levels in the substantia nigra, thus alleviating the symptoms of Parkinson's disease. The drawback of levodopa treatment is that it treats the symptoms of Parkinson's (low dopamine levels), rather than the cause (the death of dopaminergic neurons in the substantia nigra).

  3. Parkinson's disease - Wikipedia

    en.wikipedia.org/wiki/Parkinson's_disease

    Parkinson's disease (PD) is a neurodegenerative disease affecting both the central and peripheral nervous systems, characterized by the loss of dopamine-producing neurons in the substantia nigra region of the brain. [5]

  4. Pedunculopontine nucleus - Wikipedia

    en.wikipedia.org/wiki/Pedunculopontine_nucleus

    Research is being done on whether deep brain stimulation of the pedunculopontine nucleus might be used to improve the gait and postural difficulties found in Parkinson's disease. [3] [6] Clinical trials show improvement of balance and postural reactions when the pedunculopontine nucleus is electrically stimulated. [12] [13]

  5. Lewy body - Wikipedia

    en.wikipedia.org/wiki/Lewy_body

    According to the Journal of the History of the Neurosciences, Dr. Lewy became interested in studying more about the brain , because of the discovery that Alois Alzheimer made in 1906. The article mentions that the third reported case of Alzheimer's disease had histological structures that happened to be similar to Lewy body histology slides ...

  6. Parkinson’s, ADHD tied to genes that affect brain volume

    www.aol.com/parkinson-adhd-tied-genes-affect...

    Parkinson’s disease was correlated with genes linked to intracranial and subcortical brain volumes. ADHD, insomnia , and neuroticism were negatively correlated with genes controlling ...

  7. Nigrostriatal pathway - Wikipedia

    en.wikipedia.org/wiki/Nigrostriatal_pathway

    The substantia nigra is located in the ventral midbrain of each hemisphere. It has two distinct parts, the pars compacta (SNc) and the pars reticulata (SNr). The pars compacta contains dopaminergic neurons from the A9 cell group that forms the nigrostriatal pathway that, by supplying dopamine to the striatum, relays information to the basal ganglia.

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