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The dopamine hypothesis of schizophrenia or the dopamine hypothesis of psychosis is a model that attributes the positive symptoms of schizophrenia to a disturbed and hyperactive dopaminergic signal transduction. The model draws evidence from the observation that a large number of antipsychotics have dopamine- receptor antagonistic effects.
Schizoaffective disorder is a mental disorder characterized by symptoms of both schizophrenia and a mood disorder - either bipolar disorder or depression. [4] [5] The main diagnostic criterion is the presence of psychotic symptoms for at least two weeks without prominent mood symptoms. [5]
Schizophrenia is a mental disorder [17][7] characterized by hallucinations (typically hearing voices), delusions, disorganized thinking and behavior, [10] and flat or inappropriate affect. [7] Symptoms develop gradually and typically begin during young adulthood and are never resolved. [3][10] There is no objective diagnostic test; diagnosis is ...
Ketamine produces more similar symptoms (hallucinations, withdrawal) without observed permanent effects (other than ketamine tolerance). Both arylcyclohexamines have some(uM) affinity to D2 and as triple reuptake inhibitors. PCP is representative symptomatically, but does appear to cause brain structure changes seen in schizophrenia. [22]
Thought blocking. Thought blocking is a neuropsychological symptom expressing a sudden and involuntary silence within a speech, and eventually an abrupt switch to another topic. [1] Persons undergoing thought blocking may utter incomprehensible speech; they may also repeat words involuntarily or make up new words. [citation needed]
Tangential speech or tangentiality is a communication disorder in which the train of thought of the speaker wanders and shows a lack of focus, never returning to the initial topic of the conversation. [1] It tends to occur in situations where a person is experiencing high anxiety, as a manifestation of the psychosis known as schizophrenia, in ...
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