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Women are far more likely than men to get autoimmune diseases, when an out-of-whack immune system attacks their own bodies — and new research may finally explain why. ... If true, Xist by itself ...
This article provides a list of autoimmune diseases. These conditions, where the body's immune system mistakenly attacks its own cells, affect a range of organs and systems within the body. Each disorder is listed with the primary organ or body part that it affects and the associated autoantibodies that are typically found in people diagnosed ...
He noticed that many of the proteins Xist works with to bind to and silence the X chromosome had a connection to skin-related autoimmune disorders: Patients with these conditions had ...
When female cells die naturally, Dr. Howard Chang, MD, PhD, the Stanford study lead, believes that in some cases the immune system may encounter Xist molecules with several proteins attached ...
7503 213742 Ensembl ENSG00000229807 ENSMUSG00000086503 UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr X: 73.82 – 73.85 Mb Chr X: 102.5 – 102.53 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Xist (X-inactive specific transcript) is a non-coding RNA transcribed from the X chromosome of the placental mammals that acts as a major effector of the ...
Dysfuncitonal XIST proteins seem to be a leading cause of higher prevalence of autoimmune diseases of women, so as in SS. Furthermore, intestinal microbiome differences, elevated levels of certain miRNAs , and microchimerism during pregnancy are discussed and investigated as possible risk factors in the pathogenesis of SS.
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